Since 1967 when we last discussed fenfluramine (Ponderax - Selpharm)1 it has become the most widely used appetite suppressant. Though it resembles amphetamine chemically, the risk of developing dependence to it is much less; but research on its dependence-liability is still needed. Fenfluramine is effective and the anorectic effect may not fall off much with continued use for up to three months;2 tolerance to the anorectic effect of other amphetamine derivatives seems to develop more quickly. However, even if this is confirmed, strict adherence to diet and regular supervision remain essential to the long-term success of slimming regimens.
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