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Review ofDuhig KE, et al. Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial. Lancet 2019;393:1807–18.
Key learning points
Clinical diagnosis of pre-eclampsia is ambiguous and may result in repeat hospital visits and anxiety for women.
Placental growth factor (PIGF) has been shown to have high sensitivity and negative predictive value for pre-eclampsia that required delivery within 14 days.
The introduction of PIGF testing across 11 maternity units reduced the time to diagnosis by two days.
In women presenting with suspected pre-eclampsia, testing for levels of placental growth factor (PIGF) reduced time to diagnosis of pre-eclampsia and resulted in fewer severe adverse maternal outcomes.1
This randomised controlled trial in 11 UK maternity units aimed to determine whether knowing about a woman’s level of …
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