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Does evidence support vitamin D treatment for multiple sclerosis?

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Review of: Jagannath VA, et al. Vitamin D for the management of multiple sclerosis. Cochrane Database Syst Rev 2018;9:10.1002/14651858.CD008422.pub3.

Key learning points

  • It has been proposed that vitamin D supplementation could be beneficial in people with multiple sclerosis (MS).

  • This updated Cochrane review found no effect of vitamin D on relapse rates, disability or changes in parameters of disease activity.

  • The findings should be interpreted with caution because of the small numbers of studies and low quality of evidence.

A systematic review of evidence from randomised controlled trials found no benefit for vitamin D treatment for multiple sclerosis.1


This update to a previous Cochrane review assessed evidence for the use of vitamin D in the management of MS.1 It included 12 randomised controlled trials (RCTs) with 933 participants (464 were randomised to a vitamin D group and 469 to a comparator); 11 RCTs were new to this update. Trials that tested any preparation of …

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  • Contributors DTB Team.

  • Provenance and peer review Commissioned; Internally peer reviewed.