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DOACs not recommended for people with antiphospholipid syndrome

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Review of: Medicines and Healthcare products Regulatory Agency. Direct-acting anticoagulants (DOACs): increased risk of recurrent thrombotic events in patients with antiphospholipid syndrome. Drug Safety Update 2019;12(11):1.

Key learning points

  • Direct-acting oral anticoagulants are not recommended for patients with antiphospholipid syndrome.

  • Prescribers should review patients with antiphospholipid syndrome who are taking a direct-acting oral anticoagulant and consider switching to a vitamin K antagonist.

  • Patients at particularly high risk are those who are positive for all three antiphospholipid tests.

An EU-wide review has concluded that in patients with antiphospholipid syndrome use of a direct-acting oral anticoagulant could be associated with an increased rate of recurrent thrombotic events compared with therapy with a vitamin K antagonist.1

Safety alert details

The Medicines and Healthcare products Regulatory Agency (MHRA) has advised that direct-acting oral anticoagulants (DOACs) should not …

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