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Key learning points
There is inconsistent evidence for the optimal dose and duration of amoxicillin for children with community-acquired pneumonia.
A non-inferiority trial compared two doses and two treatment durations of amoxicillin prescribed for children at hospital discharge.
There was no difference in the outcome of new antibacterial prescriptions for respiratory infection between treatment groups.
A double-blind randomised trial has shown that a shorter course of treatment using a lower dose of amoxicillin is non-inferior to a higher dose and longer treatment period for young children with uncomplicated community-acquired pneumonia (CAP).1
This double-blind randomised controlled non-inferiority trial recruited 824 children aged ≥6 months (range 6 months to 8 years) who were being treated in hospital for uncomplicated CAP.1 Children were eligible if they weighed 6–24 kg, had a diagnosis of uncomplicated CAP (defined as cough within the previous 96 hours, fever ≥38°C in the previous 48 hours and laboured breathing or …
Contributors DTB Team.
Provenance and peer review Commissioned; internally peer reviewed.
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