Desensitization for hay fever and other allergies normally requires repeated injections of aqueous extracts of the allergen, at cautiously progressive doses. Twenty years ago, it was shown that a water-in-oil emulsion of antigens had a prolonged immunological effect in animals; a few years later M. H. Loveless (Amer. J. med. Sci. 1947, 214, 559) used a similar water-in-oil emulsion clinically, and many allergists have since experimented with “single visit” repository preparations.
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