RT Journal Article
SR Electronic
T1 Low-dose heparin preparations for prophylactic use
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 21
OP 22
DO 10.1136/dtb.15.6.21
VO 15
IS 6
YR 1977
UL http://dtb.bmj.com/content/15/6/21.abstract
AB Administration of low doses of heparin before and after surgery can reduce the incidence of venous thrombosis and pulmonary embolism during, and after, major operations.1 2 It is acceptably safe, except in patients with bleeding disorders. Traditional multi-dose ampoules of heparin are both inconvenient for this purpose and wasteful, and this may have hindered the widespread adoption of low-dose heparin prophylaxis. Other prophylactic measures include infusion of dextran-70,3 and rhythmical4 or graded static5 compression of the calves.