RT Journal Article SR Electronic T1 Cephradine JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 47 OP 47 DO 10.1136/dtb.11.12.47 VO 11 IS 12 YR 1973 UL http://dtb.bmj.com/content/11/12/47.abstract AB Cephradine (Eskacef - SKF; Velosef - Squibb) is a new semi-synthetic cephalosporin for oral use. Like other cephalosporins it is active against both Gram-negative and Gram-positive pathogens, apparently including penicillinase-producing staphylococci (though this has been questioned1). It is advertised as having ‘new striking power’, but from the data provided its spectrum of activity closely resembles that of cephalexin (Ceporex - Glaxo; Keflex - Lilly),2 and the promotional literature on cephradine makes no direct comparison between the two drugs.