PT - JOURNAL ARTICLE ED - , TI - Hydromet: methyldopa + hydrochlorothiazide AID - 10.1136/dtb.2.14.55 DP - 1964 Jul 10 TA - Drug and Therapeutics Bulletin PG - 55--56 VI - 2 IP - 14 4099 - http://dtb.bmj.com/content/2/14/55.short 4100 - http://dtb.bmj.com/content/2/14/55.full SO - Drug Ther Bull1964 Jul 10; 2 AB - Hydromet (MSD) is a mixture of 250 mg methyldopa with 15 mg hydrochlorothiazide in a tablet offered for the treatment of hypertension. Both drugs may lower the blood pressure when it is raised. In a double-blind trial1 a combination of the two (given in separate tablets) was found to be better than either drug alone combined with a placebo. The dose of hydrochlorothiazide was 100 mg daily and the dose of methyldopa was increased from 1 to 2 G daily after the first week.