RT Journal Article
SR Electronic
T1 Three new non-sedative antihistamines: worth keeping an eye open for
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 38
OP 40
DO 10.1136/dtb.28.10.38
VO 28
IS 10
YR 1990
UL http://dtb.bmj.com/content/28/10/38.abstract
AB Oral antihistamines are used to relieve symptoms in allergic rhinitis, conjunctivitis, urticaria and eczema. Traditional H1 receptor antagonists have sedative, and in some cases anticholinergic, side effects. A significant advance has been the development of more specific H1 antagonists in which these other properties are greatly reduced. Terfenadine and astemizole were the first;1 acrivastine (Semprex - Wellcome), cetirizine (Zirtek - A&H) and loratadine (Clarityn - Schering Plough) are three newer ones. Are they better than terfenadine and astemizole?