RT Journal Article
SR Electronic
T1 Vasoconstrictor drugs in the treatment of hypotensive states
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 73
OP 75
DO 10.1136/dtb.2.19.73
VO 2
IS 19
YR 1964
UL http://dtb.bmj.com/content/2/19/73.abstract
AB Patients with dangerously low blood pressure are often treated with drugs whose major effect is to increase the peripheral resistance, such as angiotensin (Hypertensin - Ciba), noradrenaline, methoxamine (Vasylox - BW), metaraminol (Aramine - MSD) or phenylephrine. Though these indisputably raise the blood pressure, they generally do so at the expense of a fall in cardiac output, and in man the prognosis is not necessarily improved. Indeed good theoretical reasons and abundant experimental evidence in animals (including primates) suggest that the drugs are seldom beneficial and may sometimes do harm.1