PT  - JOURNAL ARTICLE
ED  - ,
TI  - Bedtime treatment of duodenal ulcer
AID  - 10.1136/dtb.23.24.95
DP  - 1985 Dec 02
TA  - Drug and Therapeutics Bulletin
PG  - 95--96
VI  - 23
IP  - 24
4099  - http://dtb.bmj.com/content/23/24/95.short
4100  - http://dtb.bmj.com/content/23/24/95.full
SO  - Drug Ther Bull1985 Dec 02; 23
AB  - Histamine H2-receptor blockers remain the first-line drug treatment for duodenal ulcer. Cimetidine (Tagamet) was introduced in 1976 in a four times daily dosage, and ranitidine (Zantac) in 1981 in a twice daily dosage. Clinical trials have shown that the drugs are similarly effective given twice daily.1 Recently, however, treatment with a single bedtime dose of cimetidine (800mg) or ranitidine (300mg) has been advocated for the healing of duodenal ulcer. Is this simple regimen as effective as the established twice daily dosage?