RT Journal Article
SR Electronic
T1 Bedtime treatment of duodenal ulcer
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 95
OP 96
DO 10.1136/dtb.23.24.95
VO 23
IS 24
YR 1985
UL http://dtb.bmj.com/content/23/24/95.abstract
AB Histamine H2-receptor blockers remain the first-line drug treatment for duodenal ulcer. Cimetidine (Tagamet) was introduced in 1976 in a four times daily dosage, and ranitidine (Zantac) in 1981 in a twice daily dosage. Clinical trials have shown that the drugs are similarly effective given twice daily.1 Recently, however, treatment with a single bedtime dose of cimetidine (800mg) or ranitidine (300mg) has been advocated for the healing of duodenal ulcer. Is this simple regimen as effective as the established twice daily dosage?