RT Journal Article
SR Electronic
T1 Oxyphencyclimine for peptic ulcer patients?
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 83
OP 84
DO 10.1136/dtb.2.21.83
VO 2
IS 21
YR 1964
UL http://dtb.bmj.com/content/2/21/83.abstract
AB Many antispasmodic and anticholinergic drugs have been shown to reduce motility and secretion in different parts of the digestive tract, but in doses large enough to be effective these drugs invariably produce side effects. Oxyphencyclimine (Daricon - Pfizer) inhibits gastric secretion in animals without the peripheral anti-cholinergic effects seen with comparably effective gastric anti-secretory doses of other anticholinergic drugs tested. 1 Studies in man suggest that oxyphencyclimine has a selective action on the stomach, 2 that it can relieve symptoms of duodenal ulceration, 3 and that it has a prolonged action.