PT  - JOURNAL ARTICLE
ED  - ,
TI  - New drugs for hypertension – variations on old themes
AID  - 10.1136/dtb.29.6.21
DP  - 1991 Mar 18
TA  - Drug and Therapeutics Bulletin
PG  - 21--22
VI  - 29
IP  - 6
4099  - http://dtb.bmj.com/content/29/6/21.short
4100  - http://dtb.bmj.com/content/29/6/21.full
SO  - Drug Ther Bull1991 Mar 18; 29
AB  - Alpha-adrenergic blockers, calcium antagonists and some angiotensin-converting enzyme (ACE) inhibitors are now promoted as first-line drugs for the treatment of hypertension, competing with the traditional choices of β-adrenergic blockers and diuretics. The older drugs have established long-term benefits, but have some theoretical disadvantages and sometimes unwanted effects. No trials have looked at the impact of these new drugs on cardiovascular disease; studies of their efficacy have examined only immediate outcome measures such as blood pressure, and their effects on other risk factors for arterial disease such as plasma lipids. Choosing a drug for the initial treatment of hypertension has therefore become more difficult. We discuss here a new α-blocker and three recently marketed calcium antagonists.