RT Journal Article
SR Electronic
T1 Novo human insulin - the same but different
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 24
OP 24
DO 10.1136/dtb.28.6.24
VO 28
IS 6
YR 1990
UL http://dtb.bmj.com/content/28/6/24.abstract
AB Unannounced to prescribers or patients, Novo Nordisk have changed the manufacturing process of their human insulins from enzymatic modification of pig insulin (emp) to direct biosynthesis of genetically engineered yeast cells (pyr). The preservative for Human Actrapid insulin has also been changed from phenol to meta-cresol. No warning of this change was sent to pharmacists, doctors, diabetes specialists or patients.