RT Journal Article SR Electronic T1 An oestrogen patch for hormone replacement therapy JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 93 OP 95 DO 10.1136/dtb.27.24.93 VO 27 IS 24 YR 1989 UL http://dtb.bmj.com/content/27/24/93.abstract AB Oestrogen for hormone replacement therapy (HRT) is now well established for treating perimenopausal symptoms and preventing osteoporosis.1 It also protects against ischaemic heart disease and stroke.2,3 A transdermal delivery method for oestradiol (Estraderm TTS – transdermal therapeutic system) as a ‘patch’ now exists. What advantage does the patch offer over oral or implanted oestrogen?