%0 Journal Article %T A mesalazine enema for ulcerative colitis %D 1994 %R 10.1136/dtb.1994.32538 %J Drug and Therapeutics Bulletin %P 38-39 %V 32 %N 5 %X Relevant BNF section: 1.5Given by mouth, drugs based on 5-aminosalicylic acid (5-ASA) are often effective in inducing or maintaining remission in patients with ulcerative colitis.1 All of them depend on delaying the release of 5-ASA, so minimising its absorption in the small intestine and maximising delivery to the colon. With sulphasalazine (a chemical combination of 5-ASA and sulphapyridine) and olsalazine (a combination of two molecules of 5-ASA) cleavage of the azo bond by bacteria releases free 5-ASA in the colon. Oral formulations of mesalazine (the approved name for 5-ASA when given alone as a drug) use various physical mechanisms to release the 5-ASA gradually during transit through the gastrointestinal tract. Mesalazine can now be administered directly to the colon as an enema (Pentasa - Yamanouchi Pharma). How effective is this method of administering mesalazine and does it have a specific place in therapy? %U https://dtb.bmj.com/content/dtb/32/5/38.full.pdf