RT Journal Article
SR Electronic
T1 Why bother about cytochrome P450 enzymes?
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 93
OP 96
DO 10.1136/dtb.2000.381293
VO 38
IS 12
YR 2000
UL http://dtb.bmj.com/content/38/12/93.abstract
AB The cytochrome P450 system is a group of enzymes, found mainly in the liver and gut mucosa, that controls the concentrations of many endogenous substances and drugs. The activity of the individual enzymes can vary over time and from person to person in response to diet, medicines or exposure to environmental pollutants. Here, we review the cytochrome P450 system and consider its relevance to prescribing.