TY - JOUR T1 - Controlled-release budesonide in Crohn's disease JF - Drug and Therapeutics Bulletin JO - Drug Ther Bull SP - 30 LP - 31 DO - 10.1136/dtb.1997.35430 VL - 35 IS - 4 A2 - , Y1 - 1997/04/01 UR - http://dtb.bmj.com/content/35/4/30.abstract N2 - Relevant BNF section: 1.5Budesonide is a glucocorticoid with high local activity but much lower systemic availability than prednisolone. Topical formulations have long been licensed for use in asthma and rhinitis. Here we discuss a new orally active controlled-release preparation of budesonide (Entocort CR - Astra) formulated specifically for treating patients with Crohn's disease affecting the ileum and/or ascending colon. The manufacturer claims that the preparation "targets the ileum and ileocaecal area, achieving rapid results equivalent to prednisolone" with a "low level of systemic steroid side effects". ER -