PT - JOURNAL ARTICLE ED - , TI - Bupivacaine AID - 10.1136/dtb.5.21.81 DP - 1967 Oct 13 TA - Drug and Therapeutics Bulletin PG - 81--82 VI - 5 IP - 21 4099 - http://dtb.bmj.com/content/5/21/81.short 4100 - http://dtb.bmj.com/content/5/21/81.full SO - Drug Ther Bull1967 Oct 13; 5 AB - Bupivacaine (Marcain - DFE), which is advocated as a long-acting local anaesthetic, was synthesised in Sweden in 1957. Chemically bupivacaine and its predecessor mepivacaine (which is not available in this country) are related to lignocaine. Bupivacaine differs from mepivacaine in having a butyl instead of a methyl group attached to the piperidyl ring.