RT Journal Article
SR Electronic
T1 Bupivacaine
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 81
OP 82
DO 10.1136/dtb.5.21.81
VO 5
IS 21
YR 1967
UL http://dtb.bmj.com/content/5/21/81.abstract
AB Bupivacaine (Marcain - DFE), which is advocated as a long-acting local anaesthetic, was synthesised in Sweden in 1957. Chemically bupivacaine and its predecessor mepivacaine (which is not available in this country) are related to lignocaine. Bupivacaine differs from mepivacaine in having a butyl instead of a methyl group attached to the piperidyl ring.