PT - JOURNAL ARTICLE ED - , TI - Managing subclinical hypothyroidism AID - 10.1136/dtb.1998.3611 DP - 1998 Jan 01 TA - Drug and Therapeutics Bulletin PG - 1--3 VI - 36 IP - 1 4099 - http://dtb.bmj.com/content/36/1/1.short 4100 - http://dtb.bmj.com/content/36/1/1.full SO - Drug Ther Bull1998 Jan 01; 36 AB - Relevant BNF section: 6.2.1In a patient with overt primary hypothyroidism, management is usually straightforward: treatment with thyroxine should be offered to anyone with characteristic clinical features, a raised serum thyroid stimulating hormone (TSH) concentration and a low serum thyroxine (T4) concentration. More difficult is the management of a patient with subclinical hypothyroidism, in whom serum TSH is raised but T4 level is normal, and who is either asymptomatic or has only non-specific symptoms. Left untreated, some of these patients will eventually develop overt hypothyroidism. Here we discuss the use of thyroxine in patients with subclinical hypothyroidism.