RT Journal Article SR Electronic T1 â–¼Raltitrexed in colorectal cancer JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 78 OP 80 DO 10.1136/dtb.1996.341078 VO 34 IS 10 YR 1996 UL http://dtb.bmj.com/content/34/10/78.abstract AB Relevant BNF section: 8.1.3Each year about 26,000 people in Britain develop colorectal cancer. Roughly half of these patients die from locally advanced or metastatic disease. Systemic chemotherapy, usually with regimens including fluorouracil, can prolong survival in patients with advanced or recurrent disease and may improve their quality of life. â–¼Raltitrexed (Tomudex - Zeneca), a new class of cytotoxic drug introduced last year, is claimed to simplify treatment and be as effective as one established fluorouracil regimen while causing less toxicity. We review raltitrexed and assess its place in the treatment of patients in whom colorectal cancer is advanced.