RT Journal Article SR Electronic T1 â–¼Drotrecogin alfa (activated) for severe sepsis JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 5 OP 8 DO 10.1136/dtb.2006.4415 VO 44 IS 1 YR 2006 UL http://dtb.bmj.com/content/44/1/5.abstract AB Relevant BNF section: 2.11Sepsis, the systemic inflammatory response to infection, is common among severely ill patients and can be life-threatening. Over a quarter of patients in UK intensive care units (ICUs) have severe sepsis in the first 24 hours after admission.1 Of these, 35% die before leaving the ICU and 47% before leaving hospital despite standard therapy.1 â–¼Drotrecogin alfa (activated) (Xigris - Eli Lilly), a recombinant human activated protein C, is licensed for treating adults who have severe sepsis with multiple organ failure. Here we assess its efficacy and safety.