RT Journal Article SR Electronic T1 Integrin JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 51 OP 52 DO 10.1136/dtb.5.13.51 VO 5 IS 13 YR 1967 UL http://dtb.bmj.com/content/5/13/51.abstract AB Pharmacology - Oxypertine (Integrin-Bayer) has structural affinities with some major phenothiazines, such as trifluoperazine, and also with tryptophan, which has been claimed to elevate mood and increase social contacts in chronic schizophrenics.1 In animals oxypertine is a potent central depressant;2 3 it lowers body temperature, and protects mice grouped together against amphetamine toxicity, about as much as does chlorpromazine.3