PT  - JOURNAL ARTICLE
ED  - ,
TI  - Tacitin and nobrium: new drugs for anxiety
AID  - 10.1136/dtb.9.24.93
DP  - 1971 Nov 19
TA  - Drug and Therapeutics Bulletin
PG  - 93--94
VI  - 9
IP  - 24
4099  - http://dtb.bmj.com/content/9/24/93.short
4100  - http://dtb.bmj.com/content/9/24/93.full
SO  - Drug Ther Bull1971 Nov 19; 9
AB  - Pharmacologically and structurally these two drugs are quite different. Benzoctamine (Tacitin) belongs to a new chemical class, the dibenzobicyclo-octadienes.1 In animals it inhibits aggressiveness without impairing alertness, and reduces muscle tone by depressing the motor fibres to muscle spindles.2 The makers claim that it reduces muscle tension in man. Medazepam (Nobrium) is a new benzodiazepine. Structurally and pharmacologically it resembles diazepam, which is one of its metabolites.