RT Journal Article
SR Electronic
T1 Oxypertine (integrin) - now promoted’ for the treatment of anxiety
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 94
OP 95
DO 10.1136/dtb.9.24.94
VO 9
IS 24
YR 1971
UL http://dtb.bmj.com/content/9/24/94.abstract
AB We reviewed oxypertine (Integrin) in 1967, soon after it was introduced as a major tranquilliser.1 Structurally it is related to 5-hydroxytryptamine. Capsules containing a lower dose than the original tablets are now being marketed with claims that it is a ‘fundamental’ treatment for anxiety and that ‘it goes straight to the root of the problem and combats the disturbed brain-chemistry that underlies anxiety’. Like some other major tranquillisers, e.g. reserpine, oxypertine does lower amine levels in the central nervous system in animal preparations.