PT - JOURNAL ARTICLE ED - , TI - Midodrine for severe orthostatic hypotension AID - 10.1136/dtb.2016.5.0399 DP - 2016 May 01 TA - Drug and Therapeutics Bulletin PG - 54--56 VI - 54 IP - 5 4099 - http://dtb.bmj.com/content/54/5/54.short 4100 - http://dtb.bmj.com/content/54/5/54.full SO - Drug Ther Bull2016 May 01; 54 AB - Midodrine (Bramox—Brancaster Pharma Limited) was authorised in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA) in March 2015 for “the treatment of severe orthostatic hypotension due to autonomic dysfunction in adults when corrective factors have been ruled out and other forms of treatment are inadequate”.1 Previously, midodrine had only been available in the UK as an unlicensed product used on a named-patient basis. It is the first drug to be licensed in the UK for the treatment of orthostatic hypotension. Here we consider the evidence for midodrine in the treatment of severe orthostatic hypotension and how it fits with current management strategies.