PT  - JOURNAL ARTICLE
ED  - ,
TI  - High-dose antihistamines for chronic spontaneous urticaria in adults
AID  - 10.1136/dtb.2018.4.0614
DP  - 2018 Apr 01
TA  - Drug and Therapeutics Bulletin
PG  - 45--48
VI  - 56
IP  - 4
4099  - http://dtb.bmj.com/content/56/4/45.short
4100  - http://dtb.bmj.com/content/56/4/45.full
SO  - Drug Ther Bull2018 Apr 01; 56
AB  - Chronic spontaneous urticaria (CSU) is a common skin disease characterised by intermittent weals (hives), angioedema or both lasting for at least 6 weeks.1-3 Second-generation antihistamines are widely used to manage symptoms but are not completely effective in many patients at licensed doses.4 Some guidelines recommend off-label use of high-dose antihistamines as the next therapeutic step.2,3 Here, we review the evidence supporting this recommendation.