TY - JOUR T1 - High-dose antihistamines for chronic spontaneous urticaria in adults JF - Drug and Therapeutics Bulletin JO - Drug Ther Bull SP - 45 LP - 48 DO - 10.1136/dtb.2018.4.0614 VL - 56 IS - 4 A2 - , Y1 - 2018/04/01 UR - http://dtb.bmj.com/content/56/4/45.abstract N2 - Chronic spontaneous urticaria (CSU) is a common skin disease characterised by intermittent weals (hives), angioedema or both lasting for at least 6 weeks.1-3 Second-generation antihistamines are widely used to manage symptoms but are not completely effective in many patients at licensed doses.4 Some guidelines recommend off-label use of high-dose antihistamines as the next therapeutic step.2,3 Here, we review the evidence supporting this recommendation. ER -