RT Journal Article
SR Electronic
T1 High-dose antihistamines for chronic spontaneous urticaria in adults
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 45
OP 48
DO 10.1136/dtb.2018.4.0614
VO 56
IS 4
YR 2018
UL http://dtb.bmj.com/content/56/4/45.abstract
AB Chronic spontaneous urticaria (CSU) is a common skin disease characterised by intermittent weals (hives), angioedema or both lasting for at least 6 weeks.1-3 Second-generation antihistamines are widely used to manage symptoms but are not completely effective in many patients at licensed doses.4 Some guidelines recommend off-label use of high-dose antihistamines as the next therapeutic step.2,3 Here, we review the evidence supporting this recommendation.