TY - JOUR T1 - Risperidone for rapid tranquilisation: more evidence required JF - Drug and Therapeutics Bulletin JO - Drug Ther Bull SP - 134 LP - 134 DO - 10.1136/dtb.2019.000056 VL - 57 IS - 9 A2 - , Y1 - 2019/09/01 UR - http://dtb.bmj.com/content/57/9/134.abstract N2 - Review of: Ostinelli EG, Hussein M, Ahmed U, et al. Risperidone for psychosis-induced aggression or agitation (rapid tranquilisation). Cochrane Database of Syst Revs 2018;4: 10.1002/14651858.CD009412.pub2Key learning pointsThis systematic review assessed whether oral risperidone alone is an effective treatment for psychosis‐induced aggression or agitation.No studies reported on the primary outcome of tranquilisation within 30 min.Very low-quality data for the main outcomes suggested no real effect for oral risperidone.A lack of evidence for using oral risperidone for rapid tranquilisation has highlighted the need for more clinical trials evaluating oral antipsychotics in the emergency setting.1 This Cochrane review aimed to establish whether oral risperidone alone is an effective treatment for psychosis-induced aggression or agitation.1 Criteria for inclusion in the review included randomised … ER -