Table 1

Reports of hyperthermia after baclofen discontinuation/dose reduction5–7

Onset of feverTime for resolution of fever once baclofen reinstated
Mandac et al (40 mg PO QID)107°F in <24 hours24 hours
Cunningham et al (30 mg PO QID)104.9°F in 24 hours24 hours
Richter et al (560 mg per day)104°F on 4th day48 hours
Our case (40 mg PO QID)108.5°F in <24 hours24 hours
  • PO QID, orally four times per day.