Efficacy of cough suppressants in children†
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Cited by (117)
The Common Cold
2017, Principles and Practice of Pediatric Infectious DiseasesA randomized controlled trial of a homeopathic syrup in the treatment of cold symptoms in young children
2016, Complementary Therapies in MedicineCitation Excerpt :The worsening of cough in the homeopathic group at the 5–10 day follow-up is difficult to explain but might be due to a rebound effect after stopping the medication. In previous randomized controlled trials on efficacy of other types of cold medications for children, we found no evidence of effectiveness of dextromethorphan or codeine in treating nighttime cough in children, nor was Echinacea found to be effective in reducing cold symptoms.3,13 However, children with colds who were treated with medicated chest rubs had significantly more improvement than those receiving placebo or no treatment.14
Secretory hyperresponsiveness and pulmonary mucus hypersecretion
2014, ChestCitation Excerpt :Medications like guaifenesin (Robitussin, Mucinex) are meant to promote secretion clearance in patients with either acute or chronic airway disease but studies have failed to show that these are clinically effective.107,108 However, hypertonic saline (7% saline for CF) and dry powder mannitol have been shown to be effective in promoting sputum clearance in people with CF or non-CF bronchiectasis, probably by inducing an effective cough and drawing water into the airway surface liquid, unbinding secretions that are stuck to the epithelium.109,110 Secretions appear to stick to the airway epithelium in part because of surfactant inactivation.
Benzonatate Exposure Trends and Adverse Events
2022, Pediatrics
- †
Presented in part at the 31st Annual Meeting of the Ambulatory Pediatric Association, New Orleans, La., April 1991.