[HTML][HTML] How should we assess the effects of exposure to dietary polyphenols in vitro?

PA Kroon, MN Clifford, A Crozier, AJ Day… - The American journal of …, 2004 - Elsevier
Human intervention studies have provided clear evidence that dietary polyphenols (eg,
flavonoids—eg, flavonols—and isoflavones) are at least partly absorbed and that they have …

[HTML][HTML] Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity

AJ Day, MS DuPont, S Ridley, M Rhodes, MJC Rhodes… - FEBS letters, 1998 - Elsevier
Flavonoid and isoflavonoid glycosides are common dietary phenolics which may be
absorbed from the small intestine of humans. The ability of cell-free extracts from human …

Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

AJ Day, FJ Cańada, JC Dı́az, PA Kroon… - FEBS …, 2000 - Wiley Online Library
Lactase phlorizin hydrolase (LPH; EC 3.2. 1.62) is a membrane‐bound, family 1 β‐
glycosidase found on the brush border of the mammalian small intestine. LPH, purified from …

Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin

AJ Day, F Mellon, D Barron, G Sarrazin… - Free radical …, 2001 - Taylor & Francis
The position of conjugation of the flavonoid quercetin dramatically affects biological activity
in vitro, therefore it is important to determine the exact nature of the plasma metabolites. In …

Conjugation position of quercetin glucuronides and effect on biological activity

AJ Day, Y Bao, MRA Morgan, G Williamson - Free Radical Biology and …, 2000 - Elsevier
Quercetin glycosides are common dietary antioxidants. In general, however, potential
biological effects of the circulating plasma metabolites (eg, glucuronide conjugates) have …

[HTML][HTML] Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway

JM Gee, MS DuPont, AJ Day, GW Plumb… - The Journal of …, 2000 - Elsevier
Flavonoids are polyphenolic plant secondary metabolites with antioxidant and other
biological activities potentially beneficial to health. Food-borne flavonoids occur mainly as …

Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose …

AJ Day, JM Gee, MS DuPont, IT Johnson… - Biochemical …, 2003 - Elsevier
Two hypotheses on absorption mechanisms of flavonoid glucosides across the small
intestine have been proposed: active uptake of the quercetin glucoside by the sodium …

Experimental determination of octanol− water partition coefficients of quercetin and related flavonoids

JA Rothwell, AJ Day, MRA Morgan - Journal of agricultural and …, 2005 - ACS Publications
Octanol− water partition coefficient (log P) values were determined for flavonoids from the
flavone, flavonol, flavanone, and isoflavonoid subclasses. Each flavonoid was dissolved in …

Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O …

KA O'Leary, AJ Day, PW Needs, FA Mellon… - Biochemical …, 2003 - Elsevier
Quercetin-3-and quercetin-7-glucuronides are major products of small intestine epithelial
cell metabolism (J. Nutr. 130 (2000) 2765) but it is not known if quercetin glucuronides can …

Immunotherapy to improve pregnancy outcome in women with abnormal natural killer cell levels/activity and recurrent miscarriage or implantation failure: A systematic …

E Von Woon, A Day, T Bracewell-Milnes, V Male… - Journal of Reproductive …, 2020 - Elsevier
There is a trend towards offering immunotherapy to women with unexplained reproductive
failure based on abnormal Natural Killer (NK) cell levels. Previous systematic reviews …