[HTML][HTML] How should we assess the effects of exposure to dietary polyphenols in vitro?
Human intervention studies have provided clear evidence that dietary polyphenols (eg,
flavonoids—eg, flavonols—and isoflavones) are at least partly absorbed and that they have …
flavonoids—eg, flavonols—and isoflavones) are at least partly absorbed and that they have …
[HTML][HTML] Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity
AJ Day, MS DuPont, S Ridley, M Rhodes, MJC Rhodes… - FEBS letters, 1998 - Elsevier
Flavonoid and isoflavonoid glycosides are common dietary phenolics which may be
absorbed from the small intestine of humans. The ability of cell-free extracts from human …
absorbed from the small intestine of humans. The ability of cell-free extracts from human …
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
Lactase phlorizin hydrolase (LPH; EC 3.2. 1.62) is a membrane‐bound, family 1 β‐
glycosidase found on the brush border of the mammalian small intestine. LPH, purified from …
glycosidase found on the brush border of the mammalian small intestine. LPH, purified from …
Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin
AJ Day, F Mellon, D Barron, G Sarrazin… - Free radical …, 2001 - Taylor & Francis
The position of conjugation of the flavonoid quercetin dramatically affects biological activity
in vitro, therefore it is important to determine the exact nature of the plasma metabolites. In …
in vitro, therefore it is important to determine the exact nature of the plasma metabolites. In …
Conjugation position of quercetin glucuronides and effect on biological activity
AJ Day, Y Bao, MRA Morgan, G Williamson - Free Radical Biology and …, 2000 - Elsevier
Quercetin glycosides are common dietary antioxidants. In general, however, potential
biological effects of the circulating plasma metabolites (eg, glucuronide conjugates) have …
biological effects of the circulating plasma metabolites (eg, glucuronide conjugates) have …
[HTML][HTML] Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway
JM Gee, MS DuPont, AJ Day, GW Plumb… - The Journal of …, 2000 - Elsevier
Flavonoids are polyphenolic plant secondary metabolites with antioxidant and other
biological activities potentially beneficial to health. Food-borne flavonoids occur mainly as …
biological activities potentially beneficial to health. Food-borne flavonoids occur mainly as …
Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose …
AJ Day, JM Gee, MS DuPont, IT Johnson… - Biochemical …, 2003 - Elsevier
Two hypotheses on absorption mechanisms of flavonoid glucosides across the small
intestine have been proposed: active uptake of the quercetin glucoside by the sodium …
intestine have been proposed: active uptake of the quercetin glucoside by the sodium …
Experimental determination of octanol− water partition coefficients of quercetin and related flavonoids
JA Rothwell, AJ Day, MRA Morgan - Journal of agricultural and …, 2005 - ACS Publications
Octanol− water partition coefficient (log P) values were determined for flavonoids from the
flavone, flavonol, flavanone, and isoflavonoid subclasses. Each flavonoid was dissolved in …
flavone, flavonol, flavanone, and isoflavonoid subclasses. Each flavonoid was dissolved in …
Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O …
KA O'Leary, AJ Day, PW Needs, FA Mellon… - Biochemical …, 2003 - Elsevier
Quercetin-3-and quercetin-7-glucuronides are major products of small intestine epithelial
cell metabolism (J. Nutr. 130 (2000) 2765) but it is not known if quercetin glucuronides can …
cell metabolism (J. Nutr. 130 (2000) 2765) but it is not known if quercetin glucuronides can …
Immunotherapy to improve pregnancy outcome in women with abnormal natural killer cell levels/activity and recurrent miscarriage or implantation failure: A systematic …
E Von Woon, A Day, T Bracewell-Milnes, V Male… - Journal of Reproductive …, 2020 - Elsevier
There is a trend towards offering immunotherapy to women with unexplained reproductive
failure based on abnormal Natural Killer (NK) cell levels. Previous systematic reviews …
failure based on abnormal Natural Killer (NK) cell levels. Previous systematic reviews …