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Comparison of antibiotics for Clostridium difficile infection

https://doi.org/10.1136/dtb.2019.000022

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    Review of: Beinortas T, et al. Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis. Lancet Infect Dis 2018;18:1035–44.

    Key learning points

    • A comparison of 13 drug treatments for Clostridium difficile found high-quality evidence that fidaxomicin was the most effective treatment in providing a long-term cure.

    • Fidaxomicin was a better option than vancomycin for all patients except those with severe infections.

    • Metronidazole was ranked as 11th of 13 drugs in terms of efficacy.

    The authors of a network meta-analysis of drugs to treat Clostridium difficile infection have suggested that for non-multiply recurrent infections, fidaxomicin is a better option than vancomycin in all but the most severe infections, and that oral metronidazole …

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    Footnotes

    • Contributors DTB Team.

    • Provenance and peer review Commissioned; internally peer reviewed.